AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON       November 25, 1997
                                           REGISTRATION STATEMENT NO. 333-23037
    
 
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                                 ---------------
                                
   
                         POST-EFFECTIVE AMENDMENT NO. 1
                                  TO FORM SB-2/A
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                                 ---------------
    
                           SIGA PHARMACEUTICALS, INC.
                 (NAME OF SMALL BUSINESS ISSUER IN ITS CHARTER)
 
         DELAWARE                    2834                    13-3864870
     (STATE OR OTHER     (PRIMARY STANDARD INDUSTRIAL     (I.R.S. EMPLOYER    
     JURISDICTION OF      CLASSIFICATION CODE NUMBER)     IDENTIFICATION NO.) 
     INCORPORATION OR                           
      ORGANIZATION)
                                 ---------------

                                666 THIRD AVENUE
                               NEW YORK, NY 10017
                                 (212) 681-4970
                   (ADDRESS AND TELEPHONE NUMBER OF PRINCIPAL
               EXECUTIVE OFFICES AND PRINCIPAL PLACE OF BUSINESS)
                                 ---------------
            DAVID H. DE WEESE, PRESIDENT AND CHIEF EXECUTIVE OFFICER
                           SIGA PHARMACEUTICALS, INC.
                                666 THIRD AVENUE
                               NEW YORK, NY 10017
                                 (212) 681-4970
            (NAME, ADDRESS AND TELEPHONE NUMBER OF AGENT FOR SERVICE)
                                 ---------------
                                   COPIES TO:

         ADAM EILENBERG, ESQ.                    KENNETH KOCH, ESQ.
  EHRENREICH, EILENBERG, KRAUSE & ZIVIAN     SQUADRON, ELLENOFF, PLESENT
           11 EAST 44TH ST                      & SHEINFELD, LLP
          NEW YORK, NY 10017                      551 FIFTH AVENUE
            (212) 986-9700                       NEW YORK, NY 10176
       FACSIMILE (212) 986-2399                    (212) 476-8362
                                              FACSIMILE (212) 697-6686
 
  APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as
practicable after this Registration Statement becomes effective. If any of the
securities being registered on this Form are to be offered on a delayed or
continuous basis pursuant to Rule 415 under the Securities Act of 1933, check
the following box: [ ]
 
  If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, check the following box and
list the Securities Act registration statement number of earlier effective
registration statement for the same offering. [_]
 
  If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [_]
 
  If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [_]

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                                  SIGNATURES
   
   
  IN ACCORDANCE WITH THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THE
UNDERSIGNED REGISTRANT CERTIFIES THAT IT HAS REASONABLE GROUNDS TO BELIEVE
THAT IT MEETS ALL OF THE REQUIREMENTS FOR FILING ON FORM SB-2 AND AUTHORIZED
THIS REGISTRATION STATEMENT TO BE SIGNED ON ITS BEHALF BY THE UNDERSIGNED,
THEREUNTO DULY AUTHORIZED, IN THE CITY OF NEW YORK, ON THE 14TH DAY OF
NOVEMBER, 1997.     
    
 
                                          SIGA Pharmaceuticals, Inc.
 
                                                  /s/ David H. de Weese
                                          By: _________________________________
                                          David H. de Weese
                                          Chairman, President, Chief Executive
                                          Officer and Director (Principal
                                          Executive Officer)
 
  IN ACCORDANCE WITH THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THIS
REGISTRATION STATEMENT OR AMENDMENT HAS BEEN SIGNED BELOW BY THE FOLLOWING
PERSONS IN THE CAPACITIES AND ON THE DATES INDICATED:
 
SIGNATURE TITLE DATE --------- ----- ---- /s/ Joshua D. Schein Chief Financial Officer November 25, 1997 - ----------------------------------- (Principal Accounting and Dr. Joshua D. Schein Financial Officer), Executive Vice President, Secretary and Director /s/ Judson A. Cooper Executive Vice President and November 25, 1997 - ----------------------------------- Director Judson A. Cooper /s/ Terence E. Downer Director November 25, 1997 - ----------------------------------- Terence E. Downer /s/ Donald S. Howard Director November 25, 1997 - ----------------------------------- Donald S. Howard
II-1 INDEX TO EXHIBITS EXHIBIT NUMBER PAGE ------- ---- 10(o) Collaborative Research and License Agreement between the Company and American Home Products Corporation, dated as of July 1, 1997* 11(a) Statement re: Computation of per share earnings* 24(b) Consent of Price Waterhouse LLP* 27 Financial Data Scehdule - --------- * Previously filed. II-2
 


5 THIS SCHEDULE CONTAINS FINANCIAL INFORMATION EXTRACTED FROM THE FINANCIAL STATEMENT AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS. YEAR 6-MOS DEC-31-1996 DEC-31-1997 JAN-01-1996 JAN-01-1997 DEC-31-1996 JUN-30-1997 42,190 129,913 0 0 0 0 0 0 0 0 528,676 541,109 28,674 28,674 7,249 12,028 580,918 558,364 180,938 1,309,582 0 0 0 0 0 0 337 337 399,643 (751,555) 580,918 558,364 0 0 0 0 0 0 2,270,482 1,191,284 0 0 0 0 (2,306) 121,727 (2,268,176) (1,313,011) 0 0 (2,268,176) (1,313,011) 0 0 0 0 0 0 (2,268,176) (1,313,011) (.66) (.36) (.66) (.36)